精品视频在线观看专区,饥渴老熟妇乱子伦视频,五月天综合婷婷综合社,国产精品美女久久久久久小说

上海力敏實業(yè)有限公司

pall石英濾膜,millipore除菌濾膜,millipore PVDF膜,millipore聚四氟乙烯過濾膜,whatman玻璃纖維濾膜

食品機械設備網(wǎng)收藏該商鋪

您所在位置:
上海力敏實業(yè)有限公司>>胎牛血清培養(yǎng)基細胞因子>>R&D細胞因子>> RD 416-ml-010巨噬細胞生長因子Recombinant Mouse/Human M-CSF
 QQ交談
產(chǎn)品展示

RD 416-ml-010巨噬細胞生長因子Recombinant Mouse/Human M-CSF

  • 公司名稱:
  • 更新時間:
  • 所 在 地:
  • 生產(chǎn)地址:
  • 瀏覽次數(shù):
  • 食品機械設備網(wǎng)采購部電話:
  • 上海力敏實業(yè)有限公司
  • 2016-01-22 21:42:34
  • 上海市
  • 美國
  • 1264
  • 13634112423QQ:2856177234

我要詢價 具體成交價以合同協(xié)議為準

【簡單介紹】

巨噬細胞生長因子也被稱為CSF1
細胞因子,巨噬細胞的存活,增殖和分化(1)主要監(jiān)管機構纖細說明書在產(chǎn)品詳細介紹中

【詳細說明】

DESCRIPTION
Source E. coliderived
Lys33Glu262,
with an Nterminal
Met
Accession # Q3U4F9
Nterminal
Sequence
Analysis
Met
Structure / Form Disulfidelinked
homodimer
Predicted Molecular
Mass
26 kDa (monomer)
SPECIFICATIONS
SDSPAGE
29 kDa, reducing conditions
Activity Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. Halenbeck, R. et al. (1989)
Biotechnology 7:710.
The ED50 for this effect is typically 0.5-3 ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
MCSF,
also known as CSF1,
is a fourαhelicalbundle
cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 3).
MCSF
is also essential for the survival and proliferation of osteoclast progenitors (1, 4). MCSF
also primes and enhances macrophage killing of tumor cells and
microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). MCSF
increases during
pregnancy to support implantation and growth of the decidua and placenta (5). Sources of MCSF
include fibroblasts, activated macrophages, endometrial secretory
epithelium, bone marrow stromal cells and activated endothelial cells (1 5).
The MCSF
receptor (cfms)
transduces its pleotropic effects and mediates its
endocytosis. MCSF
mRNAs of various sizes occur (3 9).
Full length mouse MCSF
transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with
a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two
proteolytically cleaved, secreted dimers. One is an Nand
Oglycosylated
86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate
proteoglycan (PG) to generate a 200 kDa subunit. Although PGmodified
MCSF
can circulate, it may be immobilized by attachment to type V collagen (8). Shorter
transcripts encode M CSF
that lacks cleavage and PG sites and produces an Nglycosylated
68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7).
Although forms may vary in activity and halflife,
all contain the Nterminal
150 aa portion that is necessary and sufficient for interaction with the M CSF
receptor
(10, 11). The first 229 aa of mature mouse MCSF
shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,
respectively (12, 13). Human MCSF
is active in the mouse, but mouse MCSF
is reported to be speciesspecific.
References:
1. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
2. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
3. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
4. Ryan, G.R. et al. (2001) Blood 98:74.
5. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
6. Nandi, S. et al. (2006) Blood 107:786.
7. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
8. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
9. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
10. Koths, K. (1997) Mol. Reprod. Dev. 46:31.
11. Jang, MH.
et al. (2006) J. Immunol. 177:4055.
12. DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
13. Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.

 

上海力敏實業(yè)有限公司代理R&D產(chǎn)品,咨詢 
上海力敏實業(yè)有限公司代理R&D產(chǎn)品,咨詢 

    
留言框
感興趣的產(chǎn)品: *
留言內(nèi)容:
您的姓名: *
您的單位:
聯(lián)系電話: *
微信:
常用郵箱:
詳細地址:
省份: *
驗證碼: * =   請輸入計算結果(填寫阿拉伯數(shù)字),如:三加四=7
是否接受其他廠商報價: *
      
產(chǎn)品搜索

請輸入產(chǎn)品關鍵字:

聯(lián)系方式
地址:上海市金山區(qū)海豐路65號2286室
郵編:200000
聯(lián)系人:何經(jīng)理
留言:在線留言
商鋪:http://www.hg0881.cn/st120240/
| 商鋪首頁 | 公司檔案 | 產(chǎn)品展示 |公司動態(tài) | 詢價留言 | 聯(lián)系我們 | 會員管理 |
食品機械設備網(wǎng) 設計制作,未經(jīng)允許翻錄必究.Copyright(C) http://www.hg0881.cn, All rights reserved.
以上信息由企業(yè)自行提供,信息內(nèi)容的真實性、準確性和合法性由相關企業(yè)負責,食品機械設備網(wǎng)對此不承擔任何保證責任。
溫馨提示:為規(guī)避購買風險,建議您在購買產(chǎn)品前務必確認供應商資質(zhì)及產(chǎn)品質(zhì)量。
二維碼

掃一掃訪問手機站
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |