Biolegend LEAF Purified human CD28單抗現(xiàn)貨供應(yīng)
| Clone: | CD28.2 (See other available formats) |
| Isotype: | Mouse IgG1, κ |
| Isotype Control: | LEAF™ Purified Mouse IgG1, κ Isotype Ctrl |
| Workshop Number: | V-CD28.05 |
| Reactivity: | Human, Cross-Reactivity: Chimpanzee, Baboon, Cynomolgus, Rhesus, Pigtailed Macaque, Squirrel Monkey, Capuchin Monkey, Sooty Mangabey |
| Formulation: | 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.1 EU/µg of the protein (<0.01 ng/µg of the protein) as determined by the LAL test. |
| Preparation: | The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography. |
| Concentration: | 1.0 mg/ml |
Biolegend LEAF Purified human CD28單抗現(xiàn)貨供應(yīng)
Biolegend LEAF Purified human CD28單抗現(xiàn)貨供應(yīng)
| Description: | CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. |
| Other Names: | T44, Tp44 |
| Structure: | Ig superfamily, type I transmembrane glycoprotein, homodimer, 44 kD |
| Distribution: | Mature T cells, thymocytes, NK cell subsets, plasma cells, EBV-positive B cells |
| Function: | T cell costimulation |
| Ligand Receptor: | CD80, CD86 |
