BD human CD16流式抗體PE-CY7標(biāo)記，BD human CD16流式抗體PE-CY7標(biāo)記，

英文名：PE-Cy™7 Mouse Anti-Human CD16

克隆號(hào)：Clone  3G8  (RUO)

Brand

BD Pharmingen™

Vol. Per Test

5 µl

Isotype

Mouse BALB/c x DBA/2, also known as CD2F1 or CDF1 IgG1, κ

Reactivity

Human (QC Testing)  Rhesus, Cynomolgus, Baboon (Reported) 

Application

Flow cytometry (Routinely Tested) 

Immunogen

Human polymorphonuclear leukocytes

Workshop No.

IV N409

Entrez Gene ID

2214  2215 

Storage Buffer

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Regulatory Status

RUO

規(guī)格

 100 Tests 25 Tests 

貨號(hào)

557744

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DESCRIPTION

The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcγRIII), a human NK cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes. The 3G8 antibody is reported (Vossebeld et al., 1997) to increase intracellular calcium levels in human neutrophils by interacting with bothFcγRIIa and FcγRIIIb molecules. This antibody has also been reported to induce homotypic neutrophil aggregation.